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Pregnancy: The safety of Propofol during pregnancy has not been proven. Therefore, Propofol 10 mg/mL should only be used during pregnancy if absolutely necessary. Propofol 10 mg/ml crosses the placenta and may be associated with the depression of vital functions in newborns. Propofol can be employed as anesthesia in the case of termination of pregnancy.
High dosages (more than 2.5 mg Propofol/kg body mass for induction or 6 mg Propofol/kg of body mass per hour for maintenance of anesthesia) should be avoided.
Studies in animals have shown reproductive toxicity (see Pharmacology: Toxicology: Preclinical safety data under Actions).
Breast-feeding: Studies with breast-feeding women have shown that Propofol passes into breast milk in small quantities. Therefore, mothers should suspend breast-feeding for up to 24 hours after administration of Propofol and discard the corresponding breast milk.
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