Fixcom 2/Fixcom 3/Fixcom 4 Dosage/Direction for Use

Anti-tuberculosis short course chemotherapy recommended by World Health Organization (WHO) involves an intensive phase followed by a continuation phase for 4 months (Fixcom 2); involves an initial phase and a continuation phase (Fixcom 3); involves an initial using a combination of drugs to produce rapid killing of the tubercle bacilli (Fixcom 4).
The tablets should be taken one hour before or two hours after meals.
Fixcom 2: The dosage schedule will follow the recommended WHO TB treatment regimens. The number of tablets of fixed-dose combination tablets per patient will depend on the body weight. Hence, all patients must be weighed (using kilogram as a unit) before treatment is started. (See Table 1).

Click on icon to see table/diagram/image

Patients <55 kg: 3 tabs/day.
Patients 55-70 kg: 4 tabs/day.
Patients >70 kg: 5 tabs/day.
Fixcom 3: The continuation phase of 4-6 months using combination drugs with the aim of elimination of any remaining organisms and thus preventing recurrence.
Fixcom 4: For the initial phase: Fixcom 4 is given for 2 months.
Ethambutol should be given in reduced dosage to patients with impaired kidney function and dosage adjustments may need to be made according to serum concentrations.