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Ethambutol: Ethambutol is generally contraindicated in patients with optic neuritis. It should be generally not be used in children <6 years and some consider that it should not be used in children <13 years nor in patients with visual defects.
Fixcom 4: Pyrazinamide: Patients with liver damage, although some consider that it can be used with care when the liver damage is not severe.
Pyrazinamide should not be given to patients with acute gout or hyperuricemia.
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