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Since the administration of the Product raises the pH in the stomach, it can interact with drug absorption in the case of oral drugs, where the pH of the stomach is an important determinant of bioavailability. Therefore, the use of the Product may reduce the bioavailability of drugs that depends on the gastric pH, such as atazanavir and nelfinavir.
The Product is mainly metabolized by CYP3A4 and partially by CYP2B6, CYP2C19 and CYP2D6.
When 80 mg of the Product and clarithromycin were co-administered, the AUCT of the Product and clarithromycin were shown to be 1.1 times and 0.77 limes, respectively, which were not clinically significant.
When the Product, clarithromycin and amoxicillin were co-administered, the AUCT of amoxicillin was shown to be 0.86 times, but it was not clinically significant.
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