Fenolit Adverse Reactions

The common adverse effects of fenofibrate therapy are gastrointestinal upsets including anorexia, nausea and gastric discomfort. Other adverse effects reported to occur less frequently include headache, dizziness, vertigo, fatigue, skin rashes, pruritus, alopecia, impotence, anemia, leukopenia and thrombocytopenia. Raised serum-aminotranferase concentrations have occasionally been reported. Elevated creatinine phosphokinase concentrations during fenofibrate therapy may be associated with a syndrome of myositis, myopathy, and rarely, rhabdomyolysis. Patients with hypoalbuminemia resulting from the nephrotic syndrome or other renal impairment may be at increased risk. Fenofibrate may increase the lithogenic index. Although there have been isolated reports of gallstones, there is no evidence that the administration of fenofibrate is associated with an increased frequency of this adverse effect.