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Pharmacology: Pharmacokinetics: Fenofibrate is readily absorbed from the gastrointestinal tract when taken with food. Absorption is substantially reduced if fenofibrate is administered after an overnight fast. It is rapidly hydrolysed to its active metabolite, fenofibric acid, which is extensively bound to plasma albumin.
The plasma elimination t½ is about 20 hrs. Fenofibric acid is excreted predominantly in the urine, mainly as the glucuronide conjugate but also as a reduced form of fenofibric and its glucuronide.
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