Evaprost Mechanism of Action

Pharmacology: Carboprost trometamol administered IM stimulates the graviduterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Whether or not these contractions result from a direct effect of carboprost on the myometrium has not been determined. Nonetheless, they evacuate the products of conception from the uterus in most cases. Postpartum, the resultant myometrial contractions provides hemostasis at the site of placentation.
Carboprost trometamol also stimulates the smooth muscle of the human gastrointestinal tract. This activity may produce the vomiting or diarrhea or both that is common when it is used to terminate pregnancy and for use in postpartum. In laboratory animals and also in humans, carboprost trometamol can elevate body temperature. With the clinical doses of Evaprost used for terminating pregnancy and for use postpartum, some patients do experience transient bronchoconstriction. In laboratory animals and humans, large doses of Evaprost can raise blood pressure, probably by containing the vascular smooth muscle. With the doses of Evaprost used for terminating pregnancy, this effect has not been clinically significant.