Refractory Postpartum Uterine Bleeding: Initial Dose: 250 mcg given in deep IM. In clinical trials, it was found that the majority of successful cases (73%) responded to single injections. In some selected cases, however, multiple dosing at intervals of 15-90 min was carried out with successful outcome. The need for additional injections and the interval at which these should be given, can be determined only by the attending physicians as dictated by the course of clinical events. The total dose of Evaprost should not exceed 2 mg (8 doses).