Overdose can lead within one-two weeks to severe myelosuppression. Total doses of 2.4-3.5 g/m2 of etoposide administered intravenously over 3 days have caused mucositis and myelotoxicity. Metabolic acidosis and severe hepatic toxicity have been reported after the administration of doses that were higher than recommended. There is no specific antidote available. Treatment should therefore be symptomatic and supportive, and patients should be closely monitored.