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In case of pronounced renal insufficiency, the dosage of Cefuroxime sodium has to be reduced according to the renal function test.
The concomitant administration with other nephrotoxic drug (kanamycin, streptomycin, colistin, viomycin, polymyxin, neomycin, gentamycin, etc.) increases the renal toxicity. Consequently, the renal function has to be observed
cautiously.
The long-term administration of Cefuroxime sodium may cause the development of non-susceptible bacteria. Appropriate therapeutic measures must be taken in such cases.
The administration of cephalosporins may interfere with the results of some laboratory tests, causing false-positive reaction of the glycosuria according to the methods of Benedict, Fehling and Clinitest, but not limited in accordance with the enzyme-based tests. During treatment with cephalosporins, a false-positive result may occur in the direct Coombs test.
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