Enervon Z+ Adverse Reactions

Riboflavin (Vitamin B₂): Renal and urinary disorders: Yellow-orange discoloration to urine.
Niacinamide: Nervous system disorders: Headache, hunger pain, paresthesia (sensation of burning, stinging or tingling of the skin), syncope (fainting), vasovagal attack (sudden drop in blood pressure that may cause fainting).
Eye disorder: Blurred vision.
Cardiac disorders: Heartburn, tachycardia (fast heart rate).
Vascular disorders: Flushing (especially of the face and neck).
Gastrointestinal disorders: Abdominal distention (bloating), diarrhea, flatulence, nausea. vomiting.
Skin and subcutaneous tissue disorders: Increased sebaceous gland activity, pruritus (itching).
Pyridoxine Hydrochloride (Vitamin B₆): Although pyridoxine is generally considered to be relatively nontoxic, adverse neurologic effects have been reported following chronic administration of large pyridoxine dosages, e.g., long term administration of more than 200 mg daily.
Immune system disorders: Allergic reaction.
Psychiatric disorders: Somnolence (sleepiness).
Nervous system disorders: Headache, paresthesia (sensation of tingling, pricking or numbness of the skin).
Gastrointestinal disorders: Nausea.
Hepatobiliary disorders: Increased in serum aspartate aminotransferase (AST, a liver enzyme).
Investigations: Decreased serum folic acid concentrations.
Sodium ascorbate (Vitamin C): Blood and lymphatic system disorders: Hemolysis [after large doses of vitamin C in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency].
Immune system disorders: Delayed-type allergic response.
Psychiatric disorders: Insomnia, sleepiness.
Nervous system disorders: Headache.
Vascular disorders: Flushing.
Gastrointestinal disorders: Abdominal cramps, diarrhea (at a dose of 1 g or more daily), esophagitis (rare), flatulent distention, gastric discomfort, heartburn, intestinal obstruction (rare), nausea, transient colic, vomiting.
Renal and urinary disorders: Increased urination (mild), kidney stone formation (associated with large dosages of vitamin C reportedly have been limited to individuals with preexisting renal disease).
Injury, poisoning and procedural complications: Erosion of dental enamel.
d-Alpha-Tocopheryl Acid Succinate (Vitamin E): Vitamin E is usually well tolerated. It has been reported to rarely cause the following undesirable effects at dosages exceeding 300 IU daily which generally disappear after discontinuing the product.
Endocrine disorders: Gonadal dysfunction, thyroid problems.
Psychiatric disorders: Emotional disturbances.
Nervous system disorders: Dizziness, headache.
Eye disorders: Blurred vision.
Vascular disorders: Hypertension (increased blood pressure), thrombophlebitis (vein inflammation related to a blood clot).
Gastrointestinal disorders: Abdominal pain/intestinal cramps, diarrhea, flatulence, nausea.
Skin and subcutaneous tissue disorders: Rash.
Musculoskeletal and connective tissue disorders: Myopathy (muscle disorder).
Renal and urinary disorders: Creatinuria (increased concentration of creatinine in the urine).
Reproductive system and breast disorders: Breast soreness/gynecomastia.
General disorder and administration site conditions: Fatigue/weakness.
Investigations: Decreased serum thyroxine and triiodothyronine; increased serum creatinine kinase, serum cholesterol, triglycerides, urinary estrogens and androgens.
Doses of vitamin E greater than 1,000 mg (equivalent to 1,000 IU of dL-alpha-tocopheryl acetate) daily for prolonged periods have occasionally been associated with increased bleeding tendency in vitamin K-deficient patients such as those taking oral anticoagulants. It has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking estrogens.
Zinc: Metabolism and nutrition disorders: Loss of appetite.
Psychiatric disorders: Drowsiness.
Nervous system disorders: Headache, metallic taste.
Gastrointestinal disorders: Abdominal pain/cramps, diarrhea, dyspepsia, gastritis (inflammation of the stomach), gastrointestinal discomfort/irritation, nausea, vomiting.