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The primary anticipated complications of overdose are severe bone marrow suppression, eventually bone marrow aplasia which may be delayed by up to two weeks.
Time to occurrence of nadirs of leucocytes and thrombocytes can be 4 weeks. Even if overdosage is only suspected, long-term careful haematological monitoring is essential and supportive measures, e.g. appropriate transfusions for bone marrow suppression may be required. There is no known antidote for dacarbazine overdose. Therefore, special care has to be taken to avoid overdose of this drug.
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