Duticin Dosage/Direction for Use

It is given intravenously in doses of 2 to 4.5 mg per kg body-weight daily for 10 days, repeated at intervals of 4 weeks, or 250 mg per m² body-surface daily for 5 days, repeated at intervals of 3 weeks.
Malignant Melanoma: It can also be given in a dose of 850 mg per m² by intravenous infusion at 3-week intervals.
Hodgkin's Disease: The recommended dosage of Dacarbazine in the treatment of Hodgkin's disease is 150 mg/m²/day for 5 days, in combination with other effective drugs.
Treatment may be repeated every 4 weeks. An alternative recommended dosage is 375 mg/m²/day, in combination with other antineoplastic agents, to be repeated every 15 days.
Dosage of dacarbazine must be based on the clinical and hematologic response and tolerance of the patient in order to obtain optimum therapeutic results. Inject over 1 to 2 minutes.
Reconstitution: Reconstitute with Sterile Water for Injection. 200 mg: 20 mL.
After reconstitution, the solution should be used immediately. Reconstituted solution is stable for up to 8 hours at normal room temperatures and light or up to 72 hours at 4°C.
Precautions on Administration: Since mixing with other drugs may cause crystal formation or apparent change, the mixture injection should be avoided.
Subcutaneous or intramuscular injection should be avoided.
Since intravenous injection may cause vessel pain, injection site and injection method should be cautioned, and also the injection should be done slowly.
Extravasations of dacarbazine must be avoided as it may cause induration, sphacelism at the injection site.