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Digoxin is a cardiac glycoside used in the management of supraventricular arrhythmias, particularly atrial fibrillation, and in heart failure.
The principal actions of Digoxin are an increase in the force of myocardial contraction (positive inotropic activity) and a reduction in the conductivity of the heart, particularly in conduction through the atrioventricular (AV) node. Digoxin also has a direct action on vascular smooth muscle and indirect effects mediated primarily by the autonomic nervous system, and particularly by an increase in vagal activity. These are also reflex alterations in autonomic activity due to the effects on the circulation. Overall, these actions result in positive inotropic effects, and decreased AV nodal activity.
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