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If rapid digitalization is required then a loading dose is given to allow for the large volume of distribution. A total loading dose of 750 to 1500 micrograms of Digoxin may be given by mouth during the initial 24-hour period, either as a single dose, or when there is less urgency or greater risk of toxicity, in divided doses at 6-hourly intervals. In some patients, for example those with mild heart failure, a loading dose may not be necessary, and digitalization may be achieved more slowly with doses of 250 micrograms once or twice daily. The usual maintenance dose of Digoxin is 125 to 250 micrograms by mouth daily, but may range from 62.5 to 500 micrograms daily.
Dose should be reduced in patients with renal impairment.
Or as prescribed by the physician.
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