Cytosplat Dosage/Direction for Use

Cisplatin is administered by IV infusion. The drug has also been administered intraarterially and intraperitoneally.
Testicular Neoplasms, Bladder Cancer, Prostatic Cancer: The usual dosage of cisplatin is 15-20 mg/m² IV once daily for 5 consecutive days every 3 weeks, or administer 25-35 mg/m² once weekly according to patient's condition.
Ovarian Neoplasms: The usual dosage of cisplatin is 50-70 mg/m² once every 4 weeks, or administer following one method according to patient's condition.
Head and Neck Cancer: The usual dosage of cisplatin is 10-20 mg/m² once daily for 5 consecutive days every 3 weeks, or 50-70 mg/m² once every 4 weeks according to patient's condition.
Lung Carcinoma: The usual dosage of cisplatin is 70-90 mg/m² once every 4 weeks, or 20 mg/m² once daily for 5 consecutive days every 3 weeks according to patient's condition.
Esophageal Cancer: The usual dosage of cisplatin is 50-70 mg/m² once every 4 weeks, or 15-20 mg/m² once daily for 5 consecutive days every 3 weeks according to patient's condition.
Uterine and Neck Cancer: The usual dosage of cisplatin is 15-20 mg/m² once daily for 5 consecutive days every 3 weeks, or 70-90 mg/m² once every 4 weeks according to patient's condition.
Gastric Cancer: The usual dosage of cisplatin is 70-90 mg/m² once every 4 weeks.
Cisplatin should be added to an IV infusion fluid prior to administration; either Sodium Chloride 0.9% or Glucose 5% are suitable.
Remission of renal toxicity: Adults: Pre-treatment hydration with 1-2 liters of fluid infused for over 4 hours prior to cisplatin treatment.
Cisplatin should be added to 0.5-1 liter of an intravenous infusion fluid depending on the dosage for every 2 hours during administration; either 0.9% Sodium Chloride or Sodium Chloride 0.9% and Glucose 5%.
Adequate hydration with 1-2 liters of fluid infused for over 4 hours after cisplatin administration is recommended.
Diuresis may be aided by administration with mannitol and/or furosemide, if necessary.
Children: Pre-treatment hydration with 300-900 mL/m² of fluid infused for over 2 hours prior to cisplatin treatment.
Cisplatin should be added to 300-900 mL/m² of an intravenous infusion fluid depending on the dosage for every 2 hours during administration; either 0.9% Sodium Chloride or Sodium Chloride 0.9% and Glucose 5%.
Adequate hydration with 600 mL/m² of fluid infused for over 3 hours after cisplatin administration is recommended.
Diuresis may be aided by administration with mannitol and/or furosemide, if necessary.