Cylos Dosage/Direction for Use

The recommended dosage of Cilostazol (Cylos) is 100 mg twice a day. Doses of 150 mg twice daily were investigated, however 100 mg twice daily provided the optimal risk to benefit ratio.
Cilostazol (Cylos) should be taken 30 minutes before or two hours after breakfast and the evening meal. Taking Cilostazol with food has been shown to increase the maximum plasma concentrations (Cmax) of Cilostazol (Cylos), which may be associated with an increased incidence of adverse effects.
Cilostazol (Cylos) treatment should be initiated by a physician experienced in the management of intermittent claudication. The patient should be reassessed after 3 months of treatment with a view to discontinuing Cilostazol (Cylos) where an inadequate effect is observed or symptoms have not improved.
Patients should continue with their lifestyle modifications (smoking cessation and exercise), and pharmacological interventions (such as lipid lowering and antiplatelet treatment) to reduce the risk of cardiovascular events. Cilostazol (Cylos) is not a substitute for such treatments.
Renal Insufficiency: No dose adjustment is necessary in patients with a creatinine clearance of >25 ml/min. Cilostazol is contraindicated in patients with a creatinine clearance of <25 ml/min.
Hepatic Impairment: No dosage adjustment is necessary in patients with mild hepatic disease. There are no data in patients with moderate or severe hepatic impairment. Since Cilostazol is extensively metabolised by hepatic enzymes, it is contraindicated in patients with moderate or severe hepatic impairment.
Paediatric use: Safety and efficacy in children have not been established.
Use in the Elderly: There are no special dosage requirements for the elderly.