Cylos Contraindications

Known hypersensitivity to Cilostazol or to any of the excipients.
Severe renal impairment: creatinine clearance of < 25 ml/min.
Moderate or severe hepatic impairment.
Congestive heart failure of any grade or severity.
Pregnancy and lactation.
Patients taking inhibitors of CYP3A4 or of CYP2C19 (e.g. cimetidine, diltiazem, erythromycin, ketoconazole, lansoprazole, omeprazole and inhibitors of HIV-1 proteases).
Patients with a known predisposition to bleeding (e.g. active peptic ulceration, recent (within six months) hemorrhagic stroke, surgery within the previous three months, proliferative diabetic retinopathy, poorly controlled hypertension) or any active or uncontrolled bleeding.
Patients with a history of ventricular tachycardia, ventricular fibrillation or multifocal ventricular ectopic beats, whether or not adequately treated.
Patients with a history of severe tachyarrhythmia.
Patients treated concomitantly with two or more additional antiplatelet or anticoagulant agents (eg acetylsalicylic acid, clopidogrel, heparin, warfarin, acenocoumarol, dabigatran, rivaroxaban or apixaban).
Patients with unstable angina pectoris, myocardial infarction within the last 6 months, or a coronary intervention in the last 6 months