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Used in the treatment of various forms of malignancies such as Burkitt's and other non-Hodgkin's lymphomas, multiple myeloma and mycosis fungoides. It is also used in gestational trophoblastic tumours and malignancies of the brain, breast, endometrium, lung, and ovary; in childhood malignancies such as neuroblastoma, retinoblastoma, Wilms' tumour and in sarcomas and some leukemias.
500 mg: It is also indicated for the treatment of immune-mediated conditions such as severe rheumatoid arthritis, systemic lupus erythematosus, vasculitis, dermatomyositis, and intestitular lung disease.
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