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Initial treatment is given by intravenous injection. After satisfactory remission has occurred, maintenance therapy with tablets is recommended. Individual dosage should take into account the general state of the patient and the WBC count.
Daily IV injection of Cyclophosphamide 3-6 mg/kg body weight (120-240 mg/m2) twice weekly.
Massive Intermittent therapy - Cyclophosphamide 10-15 mg/kg body weight (400-600 mg/m2) with therapy free intervals of 7-10 days.
Massive Intermittent therapy - Cyclophosphamide 20-40 mg/kg body weight (800-1600 mg/m2) in divided doses over a period of 2-5 days with therapy free intervals of 10-20 days.
Or as prescribed by the physician.
The IV preparation is dissolved in sterile water for injection to yield a concentration of 20 mg/mL. The vials should be shaken until complete dissolution of the dry substance is obtained. A solution thus prepared is added to 250 mL 5% glucose and administered as a brief infusion of 30 min.
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