Clindagen Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Clindamycin HCl

Indications/Uses

GI & oropharyngeal infections caused by Bacteroides fragilis. Resp tract infections, pharyngitis or tonsillitis caused by Strep pyogenes. Liver abscess, actinomycosis, biliary tract infections, staphylococcal bone & joint infections, carrier state of diphtheria, gas gangrene, gynecological infections eg, bacterial vaginosis; necrotizing fasciitis, secondary peritonitis, aspiration pneumonia, pneumonia including lung abscess; septicemia, skin disorders w/ heavy strep or anaerobe colonization. In combination w/ aminoglycosides or metronidazole to treat abdomen & gut wounds, female genital tract infections, endometriosis & pelvic inflammatory disease. Prophylaxis for endocarditis in patients allergic to penicillin, surgical infection in combination w/ other drugs & to prevent perinatal streptococcal infections. Used w/ primaquine in management of pneumocystis pneumonia.

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Dosage/Direction for Use

Adult 150-300 mg every 6 hr. Severe infections Increase dose to 300-450 mg every 6 hr. Childn 3-6 mg/kg every 6 hr, <12 mth or weighing ≤10 kg 37.5 mg every 8 hr. Patient w/ high risk of endocarditis prior to surgery where penicillin is inappropriate 600 mg PO 1 hr before procedure. Patient who will undergo procedures w/ general anesth & cannot be given penicillin Injectable 300 mg 10-15 min before the procedure followed by 150 mg PO/IV after 6 hr.

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Administration

May be taken with or without food: Swallow whole w/ a full glass of water.

Contraindications

Hypersensitivity to clindamycin & lincomycin. GI disease especially w/ history of colitis. Diarrhea.

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Special Precautions

Discontinue treatment when diarrhea or colitis develops. Atopic patients. Monitor blood counts, renal & liver function during prolonged treatment. Renal & hepatic impairment. Pregnancy & lactation. Infants & childn. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Abdominal pain or cramps, nausea, vomiting, diarrhea & loose stools w/ traces of blood & mucus. Antibiotic-associated pseudomembranous colitis. Allergic rashes & urticaria, Stevens-Johnson-like syndrome, anaphylaxis, transient leukopenia, leukopenia (w/ agranulocytosis), eosinophilia, thrombocytopenia, erythema multiforme, exfoliative & vesiculobullous dermatitis, polyarthritis, abnormalities in liver function tests, overt jaundice & hepatic damage.

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Drug Interactions

Increased risk of resp depression w/ neuromuscular blockers eg, tubocurarine, pancuronium & atracurium. May exacerbate symptoms of antibiotic-associated colitis w/ diphenoxylate, loperamide & other opiate antidiarrheals. Reduced absorption rate w/ kaolin-pectin susp. Antagonism w/ parasympathomimetics eg, neostigmine & pyridostigmine.

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Storage

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Description

View Clindagen description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Other Antibiotics

ATC Classification

J01FF01 - clindamycin ; Belongs to the class of lincosamides. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Clindagen cap 300 mg

Packing/Price

100's

Clindagen

clindamycin

Manufacturer:

Nutramedica

Distributor:

Nutramedica