Rare are circulatory reactions, sweating, chills, paraesthesias and allergic reactions; these require treatment only in exceptional cases.
There have been isolated reports of inflammatory and demyelinating neurological disorders, such as progressive ascending paralysis or optic neuritis in individual cases.
On the basis of currently available data, the possibility cannot be completely excluded that in rare cases immunisation may induce an acute episode in patients with an autoimmune disorder (such as multiple sclerosis) or with an appropriate genetic predisposition. However, there is no evidence of an increased frequency of autoimmune disorders after immunisation.
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