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Experience in patients taking very high doses of Pantoprazole is limited. There has been spontaneous reports of overdosage with Pantoprazole, including a suicide in which Pantoprazole 560 mg and undetermined amounts of chloroquine and zopiclone were also ingested. There have also been spontaneous reports of patients taking similar amounts of Pantoprazole (400 mg and 600 mg) with no adverse effects. Pantoprazole is not removed by hemodialysis. In case of overdose, treatment should be symptomatic and supportive.
Single intravenous doses of Pantoprazole at 378, 230, and 266 mg/kg (38, 46, and 177 times the recommended human dose based on body surface area) were lethal to mice, rats and dogs.
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