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Film-coated tablet: Drugs which reduce gastric acidity may result in a lower bioavailability of cefuroxime axetil compared with that of the fasting state and tend to cancel the effect of enhanced absorption after food.
Cefuroxime axetil may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives.
Cefuroxime is excreted by glomerular filtration and tubular secretion. Concomitant use of probenecid is not recommended. Concurrent administration of probenecid significantly increases the peak concentration, area under the serum concentration time curve and elimination half-life of cefuroxime. Concomitant use with oral anticoagulants may give rise to increased INR.
Powder for Suspension: Probenecid reduces the renal clearance of cefuroxime. Drugs which reduce gastric acidity may result in a lower bioavailability of Cefuroxime (as Axetil) compared with that of the fasting state and tend to cancel the effect of enhanced post-prandial absorption.
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