Cefalin Capsule Drug Interactions

No potentially hazardous interactions have been reported. However, it may share the interaction potential of other cephalosporins as with the following:
Alcohol: Disulfiram-like reactions have occurred when alcohol was ingested within 48 to 72 hours after administration of β-lactam antibiotics that contain a N-methylthiotetrazole side chain. The reactions appear to result from accumulation of acetaldehyde and do not occur if alcohol is ingested prior to the first dose of antibiotic. Ingestion of alcohol during and for 24 to 72 hours after administration of some cephalosporins should be avoided.
Probenecid: Concomitant administration of oral Probenecid competitively inhibits tubular secretion resulting in higher and more prolonged serum concentrations of most cephalosporins.
Estrogens or Progestins: Some cephalosporins (e.g., ceftazidime) may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of oral contraceptives.
Metformin: When single 500 mg doses of cefalexin and metformin were given to 12 healthy subjects, plasma metformin Cmax and AUC increased by an average of 34% and 24%, respectively, and metformin's renal clearance decreased by an average of 14%. Information on the interaction of cefalexin and metformin after multiple dose administration is unavailable. Careful patient monitoring and metformin dose adjustment is recommended during concomitant therapy.
Nephrotoxic Drugs: Concurrent use of nephrotoxic agents such as aminoglycosides, colistin, polymyxin B, or vancomycin may increase the risk of nephrotoxicity with some cephalosporins and probably should be avoided, if possible.
Diuretics: Concurrent treatment with high doses of cephalosporins and potent diuretics (e.g., furosemide) may adversely affect renal function.
Other Anti-infective Agents: In vitro studies indicate that the antibacterial activity of cephalosporins against some organisms may be additive or synergistic with aminoglycosides and penicillins. Although some in vitro studies showed additive or synergistic antibacterial activity between Chloramphenicol and a cephalosporin, there is more recent in vitro evidence of antagonism between cephalosporins and Chloramphenicol against a variety of gram-negative and gram-positive bacteria, particularly when Chloramphenicol was added to the medium before β-lactam. In addition, at least one case of in vivo antagonism has been reported in an infant with Salmonella meningitis. Therefore, it is recommended that combined therapy with Chloramphenicol and a cephalosporin be avoided, particularly when bactericidal activity is considered important.
Interference with Laboratory Tests: Cefalexin capsules may cause false-positive glucose reaction in urine with Benedict's and Fehling's solutions and Clinitest tablets.
A false-positive direct Coombs' test have been reported during treatment with other cephalosporins antibiotics, therefore it should be recognized that a positive Coombs' test may be due to the drug.
Cefalexin can interfere with the alkaline picrate assay for creatinine, giving a falsely high reading, although the degree of elevation is unlikely to be of clinical importance.
The quantitative determination of urinary protein excretion using strong acids is misleading during cefalexintherapy as precipitation of cefalexin in the urine may occur.