As with other beta-blockers, Carvedilol may potentiate the effect of other concomitantly administered anti-hypertensive. Pre-treatment with rifampicin resulted in 60% decrease in Cmax and AUG receptor antagonists (e.g. clonidine) potentiate the pressor reaction which may follow sudden withdrawal of treatment with clonidine. Carvedilol, taken together with digoxin results significantly increased digoxin level. Hence, the level of digoxin should be monitored when the dose of carvedilol is initiating or adjusting or discontinuing.