Carbotinol Dosage/Direction for Use

Carboplatin should be used by the intravenous route only. The recommended dosage of carboplatin in previously untreated adult patients with normal kidney function is 400 mg/m² as a single I.V. dose administered by short-term (15-60 minutes) infusion. Therapy should not be repeated until 4 weeks after the previous carboplatin course.
Reduction of the initial dosage by 20-25% is recommended for those patients who present with risk factors such as prior myelosuppressive treatment and low performance status (ECOG-Zubrod 2-4 or Karnofsky below 80).
Dilution: The product may be diluted with 5% Glucose for injection or 0.9% Sodium Chloride for injection to concentrations as low as 0.5 mg/mL. When diluted as directed, carboplatin solutions are stable for 8 hours stored at room temperature or 24 hours stored under refrigeration. Since no antibacterial preservatives are contained in the formulation, it is recommended that any carboplatin solution be discarded after 8 hours from dilution if stored at room temperature or after 24 hours if stored under refrigeration.
Pharmaceutical Precautions: Since mixing with other drugs may cause crystal formation or apparent change, the mixture injection should be avoided.
The drug should not be diluted with aminoic acid (methionine, cysteine) containing sulfur.
When the drug is diluted with water solution containing NaCl, KCl, CaCl₂, such as physiological saline solution, it is recommended that carboplatin solution be administered within 8 hours after dilution.
Equipment containing aluminum should not be used during preparation and administration of carboplatin.
Aluminum can react with carboplatin causing precipitate formation and loss of potency.
The drug should not be injected with other antitumor agents.
The drug should be protected from light or high temperature.
Induration, necrobiosis may occur due to extravasation of the solution in intravenous injection. Therefore, intravenous administration should be taken with caution to prevent the leakage of the solution.