Sign Out
Pharmacotherapeutic Group: Antineoplastic agent. ATC Code: LO1X A02.
Carboplatin, like Cisplatin, interferes with DNA intrastrand and interstrand crosslinks in cells exposed to the drug. DNA reactivity has been correlated with cytotoxicity.
Paediatric patients: Safety and efficacy in children have not been established.
Pharmacokinetics: Following intravenous injection carboplatin exhibits a biphasic elimination and is excreted primarily in the urine, about 70% of a dose being excreted within 24 hours, almost all unchanged. Platinum slowly becomes protein bound, and is subsequently excreted with a half-life of 5 days or more; the terminal half-life of intact carboplatin is reported to be about 3 to 6 hours.
Continue with Google