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There is limited data on overdosage with candesartan in humans. Candesartan overdose will most likely manifest as hypotension, dizziness, and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.
Signs and symptoms of HCTZ overdose include hypokalemia, hypochloremia, hyponatremia, dehydration resulting from excessive diuresis, dizziness, hypotension, thirst, tachycardia, ventricular arrhythmias, sedation, and muscle cramps.
Institute symptomatic treatment and monitor vital signs if symptomatic hypotension occurs. In the event of hypotension, place the patient in supine position. For severe hypotension, administer 0.9% sodium chloride injection as IV infusion to expand fluid volume.
Monitor and correct serum electrolyte and acid imbalance.
Candesartan is not removed by hemodialysis. The degree to which HCTZ is removed by hemodialysis has not been established.
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