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Vascular toxicities coincident with the use of Bleomycin sulfate in combination with other antineoplastic agents have been reported rarely. The events are clinically heterogeneous and may include myocardial infarction, cerebrovascular accident, thrombotic microangiopathy (HUS) or cerebral arteritis.
There are also reports of Raynaud's phenomenon occurring in patients treated with Bleomycin sulfate in combination with vinblastine with or without cisplatin or, in a few cases, with Bleomycin sulfate as a single agent.
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