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Pharmacology: Pharmacokinetics: Betamethasone is rapidly absorbed from the gastro-intestinal tract upon oral administration and rapidly distributed to all body tissues. It also crosses the placenta and distributed in small amounts of breast milk.
Dexchlorpheniramine maleate is absorbed relatively slowly from the gastro-intestinal tract, peak plasma concentrations occurring about 2.5 to 6 hours after oral doses. Bioavailability is low, values of 25 to 50% having been reported. Dexchlorpheniramine appears to undergo considerable first-pass metabolism. About 70% of dexchlorpheniramine in the circulation is bound to plasma proteins. Dexchlorpheniramine is widely distributed in the body, and enters the CNS.
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