Betadex Drug Interactions

Betamethasone: Concurrent use of phenobarbital, phenytoin, rifampicin or ephedrine may enhance the metabolism of betamethasone, reducing its therapeutic effects.
Patients receiving estrogen should be observed for excessive corticosteroid effects.
Concurrent use with potassium-depleting diuretics may enhance hypokalemia. Concurrent use with cardiac glycosides may enhance the possibility of arrhythmias or digitalis toxicity associated with hypokalemia. Betamethasone may enhance the potassium depletion caused by amphotericin B.
Concurrent use with coumarin-type anticoagulants may increase or decrease the anticoagulant effects, possibly requiring adjustment in dosage.
Combined effects of non-corticosteroid anti-inflammatory drugs or alcohol with betamethasone may result in an increased occurrence or increased severity of gastrointestinal ulceration.
Dexchlorpheniramine maleate: MAO inhibitors prolong and intensify the effects of chlorpheniramine; severe hypotension may occur. Concomitant use with alcohol, tricyclic antidepressants, barbiturates or other CNS depressants may potentiate the sedative effect of dexchlorpheniramine. The action of oral anticoagulants may be inhibited by dexchlorpheniramine.