Berocca Performance Overdosage

Signs and Symptoms of Overdose: There is no evidence that this product can lead to an overdose when used as labeled.
Allowance should be made for intake of the vitamins and minerals from all other sources. General manifestation of overdose may include confusion and gastrointestinal disturbances such as constipation, diarrhea, nausea, and vomiting. If such symptoms occur, the product should be stopped and a healthcare professional consulted.
Acute or chronic overdose of the product (i.e. with intake up to 10 times the labelled dose) may cause specific toxicity associated with vitamin C, vitamin B6, or zinc.
Specific clinical signs and symptoms, laboratory findings, and consequences of overdose are highly diverse, dependent on an individual's susceptibility, and surrounding circumstances. Specific clinical manifestations (i.e. with intake of the product up to 10 times the daily dose) may include the following: Vitamin C: Acute or chronic overdose of vitamin C (>2 g/day in adults) may significantly elevate serum and urinary oxalate levels. In some instances, this result in hyperoxaluria, calcium oxalate crystalluria, calcium oxalate deposition, kidney stone formation, tubulointerstitial nephropathy, and acute renal failure.
Chronic consumption of high doses of ascorbic acid (>500 mg/day in adults) may exacerbate iron overload and result in tissue damage in patients with hemochromatosis.
Overdose of vitamin C in individuals with glucose-6-phosphate dehydrogenase deficiency (>3 g/day in children and >15 g/day in adults) may result in oxidative hemolysis or disseminated intravascular coagulation.
Vitamin B6: Intake above UL (>60 mg in adolescents 12 of age and 100 mg/day in adults) increases risk of sensory axonal neuropathy. Central effects have also been described. Neuropathy has been most commonly reported after chronic ingestion of 200 to 6000 mg/day for months or years. The neuropathy gradually improved in all cases, following removal of pyridoxine. Irreversible destruction of sensory ganglion cells (neuronopathy) may also occur after a single extremely large parenteral dose, but the exact toxic amount is not well documented in humans.
Zinc: Zinc overdose (>40 mg/day in adults) can cause diarrhea, irritation, and corrosion of the gastrointestinal (GI) tract, acute renal tubular necrosis, interstitial nephritis, copper deficiency, sideroblastic anemia and myeloneuropathies.
Calcium, Magnesium, Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B5, Vitamin B7, Vitamin B9, Vitamin B12: No discernible effects other than increase in general gastrointestinal distress are expected with intake of product of up to 10 times the daily dose due to calcium, magnesium, and vitamins B1, B2, B3, B5, B7, B9, and B12.
If overdose is suspected, the product should be stopped and a healthcare professional consulted for treatment of clinical manifestations.
What to do when the patient has taken more than the recommended dosage: There is no specific antidote however patients should still consult their physician.