Berocca Performance

For deficiency & increased requirement of vit C, B & Zn. Most water-soluble vit of B-complex & vit C are not stored by the body adequately: These are needed during extensive physical exercise or during emotional & physiological stress, & in case of chronic alcohol abuse.

Adult & adolescent >12 yr 1 effervescent tab daily.

May be taken with or without food: May be taken w/ meals for better absorption or if GI discomfort occurs. Dissolve effervescent tab in a glass of water (200 mL). Best taken in the morning.

Hypersensitivity; severe renal insufficiency (GFR <30 mL/min) including individuals on dialysis; nephrolithiasis or history of nephrolithiasis; hyperoxaluria; hypercalcemia; severe hypercalciuria.

Should not exceed labelled dose. Not for treatment of vit B₁₂ deficiency due to atrophic gastritis, disorder of the ileum or pancreas & GI malabsorption or intrinsic factor deficiency. Increased risk of adverse effects w/ acute & chronic overdose. Intake should be separated from other medications by 4 hr. Should not be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Avoid in patients w/ phenylketonuria. Consider Na content in patients on controlled Na diet. May interfere w/ lab test resulting in false reading. Caution in patients w/ hemochromatosis or G6PD deficiency. Not recommended in childn <12 yr.

Diarrhea, nausea, vomiting, GI & abdominal pains, constipation; allergic reaction, anaphylactic reaction, anaphylactic shock, hypersensitivity reactions; headache, dizziness, insomnia, nervousness; chromaturia.

Vit C: Enhanced tissue Fe toxicity w/ desferrioxamine. Reduced cyclosporine blood level. May interfere w/ effectiveness of disulfiram or warfarin. May enhance Fe absorption. May cause chemical interference in lab tests that involve oxidation-reduction reactions eg, analyses of glucose, creatinine, carbamazepine, uric acid, & inorganic phosphates in urine, serum & of occult blood in feces. May interfere w/ tests that measure urinary & blood glucose resulting in false readings. Vit B₆: Enhanced metabolism of levodopa. Vit B₁₂: Chloramphenicol may delay or interrupt reticulocyte response to vit B₁₂. Folic acid: Reduced effectiveness of MTX. Ca: Reduced urinary excretion w/ thiazide diuretics. Mg & Zn: Increased Mg &/or Zn levels could result w/ K-sparing diuretics & supplementation. Polyvalent cations (Ca, Mg, Zn): May form complexes w/ substances (eg, tetracycline/quinolone antibiotic, penicillamine, bisphosphonates, levothyroxine, methyldopa, mycophenolate mofetil, eltrombopag) resulting in decreased absorption of both substances. Oxalic acid (found in spinach & rhubarb) & phytic acid (whole cereals) may inhibit Ca, Mg & Zn absorption. Vit B₁ & B₆: May cause false +ve result in spot test w/ Ehrlich's reagent.

Vitamins &/or Minerals

A11EX - Vitamin B-complex, other combinations ; Used as dietary supplements.

Non-Rx