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Sedation may be enhanced upon concomitant use of antihistamines in general with central nervous system depressants such as barbiturates, alcohol, hypnotics, opioid analgesics, anxiolytic sedatives and neuroleptics.
The use of Cetirizine hydrochloride (Benadryl One) with drugs that inhibit the cytochrome P-450 microsomal enzymes such as azithromycin, erythromycin and ketoconazole, did not cause clinically significant changes.
Effects of alcohol and other Central Nervous System (CNS) depressants are enhanced by Cetirizine hydrochloride (Benadryl One).
Pharmacokinetic properties of ritonavir, HIV protease inhibitor, are not affected by Cetirizine hydrochloride (Benadryl One).
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