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Erythromycin, Amoxicillin, Cefixime and Ofloxacin Bromhexine (as well as ambroxol, a metabolite of bromhexine) has been shown to enhance the penetration of erythromycin, amoxicillin, cefixime and ofloxacin into bronchial secretions when administered concomitantly and has therefore been used as adjuvant treatment for respiratory infections.
Bromhexine acts by disrupting mucopolysaccharides of bronchial secretions, and as a result increases the bronchial penetration of anti-microbial drugs as evaluated on the basis of percentage penetration ratio.
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