Axibin Special Precautions

Patients with hepatic failure; renal damage; fetal infections have been associated with a combination of doxorubicin; bone marrow depression; chickenpox (fatal systemic disorder may occur).
The elderly.
Initial treatment with doxorubicin requires close observation of the patients and extensive laboratory monitoring. It is recommended, therefore, that patients should be hospitalized at least during the first phase of the treatment.
Special attention must be given to the infection and bleeding tendency exhibited by doxorubicin.
In case of prescription to a child and a patient with generative power, consider effect on sexual gland.
Precaution on Administration: Doxorubicin must not be given by the intramuscular or subcutaneous route.
Avoid intraperitoneal prescribing because of danger of intestinal obstruction.
Since intravenous administration may cause vascular pain, phlebitis, thrombus, site of injection and administration method should be cautioned, and administered as possible as slow.
Induration, necrobiosis may occur due to extravasation of the solution in intravenous injection.
Therefore, intravenous administration should be cautioned not to leak the solution.
Others: Doxorubicin imparts a red coloration to the urine after administration and patients should be advised to expect this during active therapy.
Tumors of the breast have been reported in the animal test with rat intravenously.
Use in children: Use in children should be cautioned about manifestation of adverse effects.