Axibin Dosage/Direction for Use

The solution is given via the tubing of a freely running intravenous infusion, taking 2 to 3 minutes over the injection. This technique minimizes the risk of thrombosis or perivenous extravasation which can lead to severe cellulites and vesication.
Calculated on the basis of body surface area: On this basis, 60-75 mg/m² may be given every three weeks when doxorubicin is used alone. If it is used in combination with other antitumor agents having overlapping toxicity, the dosage of doxorubicin may need to be reduced 30-40 mg/m² every three weeks.
Calculated on the basis of body weight: It has been shown that giving doxorubicin as a single dose every three weeks greatly reduces the distressing toxic effect, mucositis; however, there are still some who believe that dividing the dose over three successive days (0.4-0.8 mg/kg or 20-25 mg/m² on each day) gives greater effectiveness though at the cost of higher toxicity.
Combination with other antitumor agents having overlapping toxicity, the dosage of doxorubicin may need to be reduced 30-40 mg/m² every three weeks.
Hepatic function is impaired, doxorubicin dosage should be reduced according to the following table. (See table.)

Click on icon to see table/diagram/image

Total dosage of the drug exceeding the currently recommended limit of 550 mg/m².
It is recommended that Doxorubicin be slowly administered into the tubing of a freely running intravenous infusion of Sodium Chloride Injection, or 5% Dextrose Injection. The tubing should be attached to a needle inserted preferably into a large vein. If possible, avoid veins over joints or in extremities with compromised venous or lymphatic drainage. The rate of administration is dependent on the size of the vein and the dosage. However, the dose should be administered in not less than 2-5 minutes. Local erythematous streaking along the vein as well as facial flushing may be indicative of too rapid administration. A burning or stinging sensation may be indicative of perivenous infiltration and the infusion should be immediately terminated and restarted in another vein. Perivenous infiltration may occur painlessly. Doxorubicin should not be mixed with heparin or other drugs.