Asmalin Drug Interactions

Syrup: Sympathomimetic agents: Salbutamol should not be administered concomitantly with other sympathomimetic agents or epinephrine since serious adverse cardiovascular effects may occur.
Beta-adrenergic blocking agents (e.g., propranolol): Beta-adrenergic blocking agents may inhibit the effect of beta-agonists such as salbutamol. It may also produce severe bronchospasm in asthmatic patients.
Diuretics: Administration of nonpotassium-sparing diuretics (e.g., loop or thiazide diuretics) may result in electrocardiographic changes and/or hypokalemia and can be acutely worsened by administration of beta₂-agonists such as salbutamol, especially when the recommended dose of the beta₂-agonist is exceeded.
Digoxin: Following administration of single-dose intravenous or oral salbutamol to healthy individuals who had received digoxin for 10 days, a 16% to 22% decrease in serum digoxin concentration was observed. Although the clinical importance of these findings for patients who are receiving inhaled salbutamol and digoxin on a chronic basis is unclear, patients receiving such concomitant therapy should have their serum digoxin concentration carefully evaluated.
Monoamine oxidase inhibitors (MAOIs) or Tricyclic antidepressants (TCAs): Salbutamol should be used with caution in patients receiving MAOIs or TCAs, or within 2 weeks of discontinuation of such agents, because the effect of salbutamol on the vascular system may be potentiated. Alternative therapy should be considered in patients taking MAOIs or TCAs.
Pulmoneb: Do not use with other sympathomimetic aerosol bronchodilators or epinephrine. Administer with caution additional sympathomimetic agents by any route to patients using Salbutamol aerosol to avoid deleterious cardiovascular effects.
Concurrent administration with monoamine oxidase (MAO) inhibitors or tricyclic antidepressants may increase the risk for cardiac arrhythmia, tachycardia, and increased or decreased blood pressure.
Do not administer with beta-receptor blockers since these agents inhibit Salbutamol's effect.
The combination of nebulized Salbutamol and a nebulized anticholinergic drug has been reported to precipitate acute angle closure glaucoma and therefore should be used with caution in patients with actual or potential glaucoma.