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Aprovel is contraindicated in patients who are hypersensitive to irbesartan or to any other component of the Aprovel formulation.
Do not co-administer Aprovel with aliskiren-containing medicines in patients with diabetes or with moderate to severe renal impairment (glomerular filtration rate [GFR] <60 mL/min/1.73 m2).
Do not co-administer Aprovel with Angiotensin-Converting Enzyme Inhibitors (ACEIs) in patients with diabetic nephropathy.
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