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Selective estrogen receptor modulators (e.g., tamoxifen, raloxifene) and aromatase inhibitors (e.g., anastrozole, letrozole) should not be taken concomitantly.
Concomitant use with estrogens may diminish the action of anastrozole.
Anastrozole may inhibit the in vitro metabolic reactions catalyzed by cytochrome P-450 isoenzymes 1A2, 2C8/9, and 3A4 but only at high concentrations.
No clinically significant interaction is seen when anastrozole is administered concurrently with bisphosphonates.
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