Amoclav Dosage/Direction for Use

Tablet: Administer Co-amoxiclav at the start of a meal to minimize potential gastrointestinal intolerance and to optimize absorption.
Drink plenty of water to ensure proper state of hydration and adequate urinary output.
Treatment should not exceed 14 days without first re-evaluating the patient.
Usual Oral Dosage in Adults and Children over 12 years old: See Table 4.

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Dosage in Adults and Children over 12 years old with Renal Impairment: See Table 5.

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Dosage in Adults and Children over 12 years old on Hemodialysis: Co-amoxiclav 375 mg OR 625 mg tablet every 24 hours, depending on the severity of infection. Patients should receive an additional dose both during and at the end of dialysis.
Dosage in Adults and Children over 12 years old with Hepatic Impairment: Dose with caution and monitor hepatic function regularly.
Powder for injection: Co-amoxiclav may be administered either by IV injection or by intermittent infusion. It is NOT suitable for intramuscular (IM) administration.
Co-amoxiclav should be given by slow IV injection over a period of 3 to 4 minutes and within 20 minutes of reconstitution. It may be injected into the vein or via drip tube.
Treatment should not exceed 14 days without re-evaluation of the patient.
Usual Recommended IV Co-amoxiclav Dose: (See Table 6.)

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Dosage for Surgical Prophylaxis: Surgical prophylaxis with Co-amoxiclav should aim to protect the patient for the period of risk of infection.
In adults, procedures lasting less than 1 hour are successfully covered by IV Co-amoxiclav 1.2 g (Amoxicillin 1000 mg + Clavulanic acid 200 mg) administered at induction of anesthesia.
Longer operations or when there is a high risk of infection (e.g., colorectal surgery) may require subsequent doses of IV Co-amoxiclav 1.2 g (Amoxicillin 1000 mg + Clavulanic acid 200 mg) [up to 4 doses in 24 hours], and this regimen can be continued for several days if the procedure has significantly increased the risk of infection.
Clear clinical signs of infection at operation will require a normal course of IV or oral Co-amoxiclav therapy post-operatively.
Dosage in Elderly Patients: No dosage adjustment necessary. However, if there is evidence of renal impairment, dose should be adjusted as for renally-impaired adults.
Dosage in Patients with Renal Impairment: Dosing adjustments are based on the maximum recommended level of amoxicillin. (See Table 7.)

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Dosage in Patients with Hepatic Impairment: Dose with caution; monitor hepatic function at regular intervals for both adults and children.
Data on where to base the dosage recommendation have not been established.