Amoclav Caution For Usage

Powder for injection: Directions for Use: Directions for Reconstitution: To reconstitute, dissolve IV Co-amoxiclav powder in the required amount of diluent (Water for injection is the usual diluent). (See Table 9.)

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There are two ways of administering IV Co-amoxiclav: Slow IV injection for 3 to 4 minutes after reconstitution.
IV infusion over 30 to 40 minutes (should be further diluted after reconstitution).
Preparation of IV Infusion and Stability: Add without delay (i.e., Solutions should be made up to full infusion volume immediately after reconstitution) Co-amoxiclav 600 mg (500 mg/100 mg) reconstituted solution to 50 mL infusion fluid OR 1.2 g (1000 mg/200 mg) reconstituted solution to 100 mL infusion fluid (preferably using a mini-bag or in-line burette). Infuse over 30 to 40 minutes and complete within the time stated.
Satisfactory antibiotic concentrations are retained at 5°C and at room temperature (25°C) in the recommended volumes of the following infusion fluids. If reconstituted and maintained at room temperature, infusions should be completed within the time stated. (See Table 10.)

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Reconstituted solution should not be frozen.
For storage at 5°C, the reconstituted solution should be added to pre-refrigerated infusion bags which may be stored for up to 8 hours.
Thereafter, the infusion should be administered immediately after reaching room temperature. (See Table 11.)

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Co-amoxiclav vials are not suitable for multi-dose use. Any unused antibiotic should be disposed properly.
Co-amoxiclav IV is less stable in infusions containing glucose, dextran or bicarbonate. Therefore, reconstituted solution should not be added to such infusions but may be injected into the drip tubing over a period of 3 to 4 minutes.
Incompatibilities: Co-amoxiclav IV should not be mixed with blood products, other proteinaceous fluids such as protein hydrolysates or with IV lipid emulsions. If Co-amoxiclav injection is prescribed concomitantly with an aminoglycoside, the antibiotics should not be mixed in the syringe, IV fluid or giving set because of loss of activity of the aminoglycoside under these conditions.