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Pharmacotherapeutic group: Amiodarone hydrochloride is an antiarrhythmic.
Pharmacology: Pharmacokinetics: Amiodarone is absorbed variably and erratically from the gastrointestinal tract. It is extensively distributed to body tissues and accumulates notably in muscle and fat; it has been reported to be about 96% bound to plasma proteins. The terminal elimination half-life is about 50 days with a range of about 20 to 100 days due to its extensive tissue distribution.
A major metabolite has antiarrhythmic properties. There is very little urinary excretion of Amiodarone or its metabolites, the major route of excretion being in faeces via the bile; some enterohepatic recycling may occur. Amiodarone and desethylamiodarone are reported to cross the placenta and to be distributed into the breast milk. After intravenous injection, the maximum effect is achieved within 1 to 30 minutes and persists for 1 to 3 hours.
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