Amiron Dosage/Direction for Use

The minimum effective dose should be used at all times. Dosage should be adjusted according to individual patient's response and well being. The following dosage regimen is generally effective.
Initial stabilization: initiate treatment with 200 mg three times daily for one week. Reduce this dosage to 200 mg twice daily.
Maintenance: following the initial stabilization period, the dosage should be reduced to 200 mg daily, or less, if appropriate. The scored 100 mg tablet should be used to titrate the minimum dosage. The maintenance dose should be regularly reviewed, especially when this exceeds 200 mg daily.
Or as prescribed by the physician.
Pediatric population: No controlled paediatric studies have been undertaken.
In published studies, the safety of Amiodarone was evaluated in 1118 pediatric patients with various arrhythmias.
The following doses were used in pediatric clinical trials.
Oral: Loading dose: 10 to 20 mg/kg/day for 7 to 10 days (or 500 mg/m²/day if expressed per square meter).
Maintenance dose: The minimum effective dosage should be used; according to individual response, it may range between 5 to 10 mg/kg/day (or 250 mg/m²/day if expressed per square meter).
Intravenous: Loading dose: 5 mg/kg body weight over 20 minutes to 2 hours.
Maintenance dose: 10 to 15 mg/kg/day from a few hours to several days.
If needed, oral therapy may be initiated concomitantly at the usual loading dose.