Algesia Dosage/Direction for Use

Tramadol + paracetamol can be administered with or without food and is for oral use only. Tablets should be swallowed, with a sufficient quantity of liquid.
The dose should be individually adjusted according to the intensity of pain and response of the patient.
Adults and children over 16 years old: Orally, one to two tablets every four to six hours, as needed for pain relief, or, as prescribed by a physician.
Maximum: Eight tablets per day.
Elderly patients: In patients over 75 years old, it is recommended that the minimum interval between doses should not be less than six hours.
Renal impairment (creatinine clearance < 30 mL/min): It is recommended that the dosing interval of tramadol + paracetamol should be prolonged, and the dose should not exceed 75 mg of tramadol and 650 mg of paracetamol (two tablets) every 12 hours. As tramadol is removed only very slowly by hemodialysis or by hemofiltration, post-dialysis administration to maintain analgesia is not usually required.
Hepatic impairment: In patients with moderate hepatic impairment, prolongation of the dosage interval should be carefully considered.