Algesia Adverse Reactions

Tramadol + Paracetamol: The most frequently reported adverse effects are abdominal pain, anorexia, constipation, diarrhea, dizziness, dry mouth, dyspepsia, fatigue, flatulence, headache, hot flushes, hypertension, hypoesthesia, increased sweating, influenza-like symptoms, insomnia, nausea, nervousness, prostatic disorder, pruritus, rash, somnolence, trembling, and vomiting.
Blood and lymphatic system disorders: Agranulocytosis, anemia, granulocytopenia, leukocytosis, thrombocytopenic purpura.
Immune system disorders: Acute generalized exanthematous pustulosis, allergic reactions, anaphylaxis, bronchospasm, Stevens-Johnson Syndrome, toxic epidermal necrolysis, urticaria.
Metabolism and nutrition disorders: Hypoglycemia, hyponatremia.
Psychiatric disorders: Abnormal thinking, anxiety, cognitive dysfunction, confusion, depression, drug abuse, drug dependence, emotional lability, euphoria, hallucinations, mental status changes, mood changes, nervousness, panic attacks, paroniria, sleep disorders, stupor, suicidal tendency.
Nervous disorder: Abnormal dreams, agitation, amnesia, ataxia, coma, convulsions, difficulty concentrating, dyskinesia, dystonia, hyperreflexia, involuntary muscle contractions, migraine, paresthesia, seizure, syncope, tremor, vertigo. Eye disorders: Abnormal vision, blurred vision.
Ear and Labyrinth disorders: Tinnitus.
Cardiac disorders: Arrhythmia, chest pain, dependent edema, myocardial ischemia, palpitation, pulmonary edema, tachycardia.
Vascular disorders: Aggravated hypertension, cardiovascular collapse, hypertension, hypotension, orthostatic hypotension, syncope, vasodilation.
Respiratory, thoracic and mediastinal disorders: Dyspnea.
Gastrointestinal disorders: Abdominal pain, dysphagia, gastrointestinal bleeding, melena, tongue edema.
Hepatobiliary disorders: Hepatitis, hepatotoxicity, liver failure.
Skin and subcutaneous tissue disorders: Dermatitis, erythematous rash, urticaria.
Musculoskeletal and connective tissue disorders: Arthralgia, hypertonia, rigors, shivers.
Renal and urinary disorders: Albuminuria, dysuria, micturition disorders, urinary retention, oliguria.
Reproductive system and breast disorders: Impotence, prostatic disorder.
General disorders and administration site conditions: Asthenia, fever, diaphoresis, withdrawal syndrome.
Investigations: Abnormal hepatic function, alterations in liver function test values, decreased weight, increased alkaline phosphatase, increased ALT, increased aspartate transaminase (AST), increased coagulation time, increased weight
Tramadol: The most frequently reported adverse effects are dizziness and nausea. Other common effects include abdominal pain, anorexia, anxiety, confusion, constipation, coordination disturbance, dry mouth, euphoria, flatulence, headache, hypertonia, malaise, menopausal symptoms, miosis, nervousness, rash, sleep disorder, somnolence, insomnia, urinary frequency, urinary retention, vasodilation, visual disturbance, and vomiting.
Blood and lymphatic system disorders: Blood dyscrasias.
Infections and infestations: Cellulitis, epididymitis, pneumonia.
Immune system disorders: Allergic reactions, anaphylaxis, angioedema, bronchospasm, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, vesicles.
Endocrine disorders: Androgen deficiency, syndrome of inappropriate antidiuretic hormone secretion.
Metabolism and nutrition disorders: Adrenal insufficiency, changes in appetite, edema, hypoglycemia, hyponatremia.
Psychiatric disorders: Changes in activity (usually suppression, occasionally increase), changes in cognitive capacity and sensorial capacity (e.g., decision behavior, perception disorders), depersonalization, depression, derealization, delusions, difficulty in attention, dysphoria, elation, emotional lability, hallucinations, hyperactivity, hypoactivity, mental status changes, mood changes, nightmares, panic attacks, suicidal tendencies.
Nervous system disorders: Abnormal dreams, abnormal gait, agitation, amnesia, asthenia, cognitive disorder, convulsions, CNS stimulation, coma, delirium, difficulty in concentration, disorientation, dysgeusia, dyskinesia, dystonia, epileptiform convulsions, hyperkinesia, hyperreflexia, involuntary muscle contractions, irritability, migraine, motor weakness, movement disorder, paresthesia, seizure, sedation, serotonin syndrome, spasticity, speech disorders, trembling, tremor, vertigo.
Eye disorders: Blurred vision, cataracts, mydriasis.
Ear and Labyrinth disorders: Deafness, tinnitus.
Cardiac Disorders: Arrhythmia, bradycardia, cardiac arrest, chest pain, myocardial infarction, myocardial ischemia, palpitations, pulmonary edema, tachycardia.
Vascular disorders: Circulatory depression, flushing, hot flushes, hypertension, hypotension, orthostatic dysregulation (tendency to collapse and cardiovascular collapse), orthostatic or postural hypotension, peripheral ischemia, shock, syncope.
Respiratory, thoracic and mediastinal disorders: Apnea, coughing, dyspnea, nasal symptoms, nasopharyngitis, pulmonary embolism, respiratory arrest, respiratory depression, sinusitis, sneezing, upper respiratory tract infection, wheezing, worsening of asthma, yawning.
Gastrointestinal disorders: Appendicitis, bloating, diarrhea, dyspepsia, dysphagia, gastritis, gastroenteritis, gastrointestinal bleeding, gastrointestinal irritation (feeling of pressure in the stomach), pancreatitis, retching, sore throat, stomatitis, toothache.
Hepatobiliary disorders: Cholecystitis, cholelithiasis, hepatitis, liver failure.
Skin and subcutaneous tissue disorders: Dermatitis, piloerection, pruritus, sweating.
Musculoskeletal and connective tissue disorders: Arthralgia, joint stiffness, joint swelling, muscle cramps, muscle injury, muscle spasms, muscle twitching, musculoskeletal pain, myalgia, osteoarthritis aggravated, rigors, shivering.
Renal and urinary disorders: Dysuria, hematuria, micturition disorder, proteinuria, urinary tract infection.
Reproductive system and breast disorders: Amenorrhea, decreased libido, erectile dysfunction, impotence, infertility, menstrual disorder.
General disorders and administration site conditions: Asthenia, clamminess, death, dependence, diaphoresis, fatigue, fever, hyperthermia, influenza-like symptoms, jittery feeling, lethargy, peripheral swelling, pyrexia, withdrawal syndrome.
Investigations: Abnormal electrocardiogram (ECG), decreased hemoglobin, elevated liver enzymes, increased blood creatine phosphokinase, increased blood glucose concentrations, increased creatinine, weight decreased.
Injury, poisoning and procedural complications: Accidental injury, contusions, falls, joint sprain.
Paracetamol: Paracetamol, when taken within the recommended dose and duration of treatment, has low incidence of side effects. The most common side effects are constipation, headache, insomnia, nausea, and vomiting.
Blood and lymphatic system disorders: Agranulocytosis, anemia, blood dyscrasias, jaundice, leukopenia, methemoglobinemia, neutropenia, pancytopenia, thrombocytopenia, thrombocytopenic purpura Infections and infestations: Colds, infections.
Immune system disorders: Acute generalized exanthematous pustulosis, allergic reactions, anaphylactoid reactions, anaphylaxis, angioedema, hypersensitivity reactions, laryngeal edema, periorbital edema, swelling of the face, mouth, or throat, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria.
Metabolism and nutrition disorders: Loss of appetite.
Respiratory, thoracic, and mediastinal disorders: Bronchospasm, breathing problems, respiratory distress, severe asthma episode.
Gastrointestinal disorders: Minor stomach and intestinal disturbances, mouth ulcers.
Hepatobiliary disorders: Acute liver failure, hepatic dysfunction, hepatotoxicity.
Skin and subcutaneous tissue disorders: Maculopapular rash, peeling, pruritus, rash.
Renal and urinary disorders: Kidney damage.
General disorders and administration site conditions: Unusual tiredness.
Investigations: Increased alanine transaminase (ALT), sudden weight loss.
Injury, poisoning and procedural complications: Unexplained bruising or bleeding.