Aldren 70 Drug Interactions

It is likely that calcium supplements, antacids, and some oral medications will interfere with absorption of alendronate sodium. Therefore, patients must wait at least one-half hour after taking alendronate sodium tablets before taking any other oral medications. In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products. Since NSAID use is associated with gastrointestinal irritation, caution should be used during concomitant use with alendronate sodium tablets. Intravenous ranitidine was shown to double the bioavailability of oral alendronate sodium. The clinical significance of this increased bioavailability and whether similar increases will occur in patients given oral H2-antagonists is unknown. In healthy subjects, oral prednisone (20 mg three times daily for five days) did not produce a clinically meaningful change in the oral bioavailability of alendronate sodium (a mean increase ranging from 20 to 44%).