Akticib Adverse Reactions

The most common adverse effects of NSAIDs are generally gastrointestinal disturbances, such as gastrointestinal discomfort, nausea, and diarrhea; these are usually mild and reversible, but in some patients peptic ulceration and severe gastrointestinal bleeding may occur. It is generally agreed that inhibition of cyclo-oxygenase-1 (COX-1) plays an important role in the gastrointestinal effects of NSAIDs; the selective inhibition of COX-2 improves gastrointestinal tolerance.
CNS-related adverse effects include headache, vertigo, dizziness, nervousness, tinnitus, depression, drowsiness, and insomnia. Hypersensitivity reactions may occur occasionally and include fever; angioedema, bronchospasm, and rashes. Hepatotoxicity and aseptic meningitis which occur rarely, may also be hypersensitivity reactions. Some patients may experience visual disturbance.
Hematological adverse effects of NSAIDs include anemia, thrombocytopenia, neutropenia, eosinophilia, and agranulocytosis. Unlike aspirin, inhibition of platelet aggregation is reversible with other NSAIDs.
Some NSAIDs have been associated with nephrotoxicity such as interstitial nephritis and nephrotic syndrome; renal failure may be provoked by NSAIDs especially in patients with pre-existing renal impairment.
Hematuria has also occurred. Long-term use or abuse of analgesic, including NSAIDs, has been associated with nephropathy.
Fluid retention may occur, rarely precipitating heart failure in susceptible patients.
Other adverse effects include photosensitivity, alveolitis pulmonary eosinophilia, pancreatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis are other rare adverse effects.
Induction or exacerbation of colitis has also been reported.
Etoricoxib should not be used in patients with hypertension whose blood pressure is controlled.
Etoricoxib is also contraindicated in patients with inflammatory bowel disease, moderate to severe heart failure, and renal impairment associated with creatinine clearance of less than 30 mL/minute.