Dextromethorphan Hydrobromide, Phenylpropanolamine Hydrochloride, Chlorpheniramine Maleate, Sodium Citrate.
Formulation: Phenylpropanolamine HCl 10 mg, Dextromethorphan HBr 15 mg, Chlorpheniramine Maleate 2 mg, Sodium Citrate 200 mg.
Pharmacology: Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain by binding to the NMDA glutamatergic receptor.
Phenylpropanolamine acts directly on alpha- and beta-adrenergic receptors in the mucosa of the respiratory tract. Stimulation of alpha-adrenergic receptors produces vasoconstriction, reduces tissue hyperemia, edema, and nasal congestion, and increases nasal airway patency.
Chlorpheniramine binds to the histamine (H1) receptor and blocks the action of endogenous histamine- such as pruritic, vasodilation, flushing and bronchoconstriction.
Sodium Citrate is absorbed from the GI tract within two hours, and is largely eliminated through hepatic metabolism with very little cleared by the kidneys.
For coughs associated with colds, influenza, bronchitis, pharyngitis, laryngitis and other respiratory diseases whether allergic or non-allergic in nature.
Children (1-9 yrs. old): 2.5-5 mL (½-1 teaspoonful).
Adults: 5-10 mL (1-2 teaspoonful).
To be taken every 4 hours or as prescribed by the physician.
Do not use continuously for more than one week.
Overdosage of AC-NEX PH Syrup, might cause drowsiness, blurred vision, confusion, hallucination, fever and seizure. Seek emergency medical attention if the patient suspects that they or anyone else have overdosed of AC-NEX PH Syrup.
Bring medicine box, container, or label with the patient to help doctors with necessary information.
This product is not given to patients allergic to any of the ingredients and to patients with renal disease.
Dextromethorphan is contraindicated in patients with asthma as it causes release of histamines.
Patients with the following conditions should be careful in taking Phenylpropanolamine (PPA): high blood pressure, toxic goiter, benign prostatic hypertrophy, heart rate irregularity, glaucoma and if taking antidepressants.
This product contains FD & C yellow #5 (Tartrazine) which may cause allergic type reactions (including Bronchial Asthma) in certain susceptible persons.
Consult the doctor before taking Phenylpropanolamine (PPA) if the patient thinks they have the following conditions: heart disease, uncontrolled/untreated high blood pressure.
Antihistamines may cause drowsiness and dulling of mental alertness where loss of attention may lead to accidents. This product may be given to pregnant and nursing women if benefit outweighs the risk.
Adverse reactions include drowsiness, abdominal pain, diarrhea, constipation, headache, thickening of bronchial secretions, urinary retention, increased risk of hemorrhagic stroke due to Phenylpropanolamine, CNS depression.
Dextromethorphan HBr: Decreased metabolism when taken with celecoxib, chloramphenicol, vitamin D; increased serum levels when taken with colchicine, doxorubicin, and phenytoin; increase the serotonergic activities with sertraline, toloxatone, alosetron, amphetamine and citalopram.
Phenylpropanolamine HCl: Decreased broncho dilatory effects by beta-blockers, clozapine; hypokalemia when taken with diuretics.
Chlorpheniramine maleate: Alcohol, antihistamines, CNS depressants, and sedatives.
Sodium citrate: Warfarin, NSAIDs, alteplase, diuretics, barbiturates, buclizine, calcium salts and aspirin.
R05DA20 - combinations ; Belongs to the class of opium alkaloids and derivatives. Used as cough suppressant.
AC-NEX PH syr
120 mL x 1's;60 mL x 1's
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